Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Gastroenterology & Hepatology [Category] SARS, 진단, [키워드] adjusted age All participant anti-SARS-CoV-2 anti-TNF antibody Antibody binding antibody concentration Antibody concentrations approved available data boost booster case-control study combination therapy Concentration control group COVID-19 COVID-19 vaccine Diagnosis disease dose Evidence first dose geometric mean geometric mean ratio group groups had no healthy control healthy individuals heterologous vaccine homologous IBD Immunosuppressed immunosuppressed patient immunosuppressive Immunosuppressive treatment Infection Inflammatory bowel disease jak inhibitors multicentre multivariable nine no significant difference Older Older age participant Patient patients treated Pfizer Primary outcome receiving Receptor binding domain recipient recruited reduced regimen response S1 RBD SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination significantly significantly lower Support T-cell Response T-cell responses the healthy therapy Tofacitinib Treatment ulcerative colitis Vaccine vaccine dose vaccine doses vaccine-induced antibody response VIP were measured [DOI] 10.1016/S2468-1253(22)00274-6 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
Decoding the effects of spike receptor binding domain mutations on antibody escape abilities of omicron variantsArticle Published on 2022-10-302022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities antibodies antibody Antibody binding antibody escape appear approach approved binding affinity binding free energy cause Coverage COVID19 decrease Effect evaluate globe hotspot immune evasion immunogenic Immunogenic hotspot immunoinformatics K417N monoclonal antibody mutant Mutation mutations omicron Omicron variant Omicron variants Omicron variants. Point mutation RBD mutation RBD-specific antibody recent Receptor binding domain reduce reduction in REGN10987 residue selection pressure significantly single mutation the binding affinity therapeutic vaccination variants [DOI] 10.1016/j.bbrc.2022.08.050 PMC 바로가기
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitopeArticle Published on 2022-10-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody binding Antibody Response association competing cryo-EM Delta delta variant disrupt elicit epitope evade host immune responses hydrophobic immune evasion immune response impair inhibiting Interaction L452R Lineage mechanism Mutation neutralization omicron Population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike receptor-binding domain spike variants Spread Substitution substitutions target thought variant virus entry virus variants [DOI] 10.1038/s41564-022-01235-4 PMC 바로가기
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen testsArticle Published on 2022-09-152022-11-15 Journal: Cell [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody Antibody binding Antigen Complete COVID-19 patient deep deep mutational scanning diagnostic Effect Emergency use authorization epitope epitope mapping escape mutation evaluate identify mammalian mammalian surface-display Mutation platform Point mutation predict profile public health rapid antigen test Rapid antigen tests Rapid diagnostic tests SARS-CoV-2 SARS-CoV-2 nucleocapsid protein susceptibility the antibody utility valuable resource variants variants of concern variants of SARS-CoV-2 variants. [DOI] 10.1016/j.cell.2022.08.010 PMC 바로가기
Loss of Pfizer (BNT162b2) Vaccine-Induced Antibody Responses against the SARS-CoV-2 Omicron Variant in Adolescents and AdultsArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Adolescent adolescents adolescents and adult adolescents and adults Adults age antibody Antibody binding antibody binding titers approved Beta binding binding antibody BNT162b2 BNT162b2 vaccine booster booster dose booster vaccination breadth changes in children circulating clinical trial Cohort Coverage COVID-19 Delta demonstrated dose drug Effectiveness Efficacy evaluate FDA food Gamma highlight Hospitalization humoral immune response lack less Loss magnitude mounted mRNA vaccine neutralization Neutralizing antibody response omicron Omicron (B.1.1.529) pandemic pediatric Pfizer Pfizer-BioNTech Pfizer-BioNTech (BNT162b2) plasma populations PROTECT reduction reported Research response responses against robust SARS-CoV-2 seasonal beta coronavirus the antibody response the SARS-CoV-2 the vaccine vaccination Vaccine vaccine-induced antibody response Vaccine-induced immunity variant variant of concerns (VOCs) variants viral variant Virus neutralization virus neutralization. virus spike protein VoC VOCs while wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00582-22 PMC 바로가기
Production of novel SARS-CoV-2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodiesArticle Published on 2022-09-012022-11-15 Journal: Biotechnology Journal [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Antibody binding antibody binding. binding Cell cells Chinese hamster Chinese hamster ovary cells COVID-19 develop diagnostics domain eight elicit evaluated Express expressed expression full-length IMPROVE Infection Modification monoclonal antibody outperform platform polyclonal Production Protein purified pursuit raised RBD Research responses SARS-CoV-2 sensitivity serological assays significantly spike the Spike vaccination viral entry [DOI] 10.1002/biot.202100678 PMC 바로가기
Humoral immune response characterization of heterologous prime-boost vaccination with CoronaVac and BNT162b2CoronaVac 및 BNT162b2를 사용한 이종 프라임-부스트 백신 접종의 체액 면역 반응 특성화Article Published on 2022-08-192022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ADCC ADCP Analysis anti-RBD anti-RBD IgG antibody antibody Antibody binding assays baseline binding domain binding kinetics BNT162b2 booster Cohort CoronaVac coronavirus decrease dose elapsed enrolled evaluated Fc-mediated function Fc-mediated functions Follow-up General population healthy individual Heterologous heterologous prime-boost heterologous vaccination high correlation humoral immune response IgG antibody IgG level immune immune response increase in individual Interaction mechanisms Neutralization assay Participants Prevent Prospective Study RBD RBD-ACE2 remained reporter SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Seroconversion serological seronegative serum severe infections significantly to define vaccination vaccination schedule Vaccine [DOI] 10.1016/j.vaccine.2022.07.023 PMC 바로가기 [Article Type] Article